Pyripyropenes, novel inhibitors of acyl-coa: Cholesterol acyltransferase produced by aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D

Abstract

The structures of pyripyropenes A, B, C and D, novel acyl-CoA : cholesterol acyltransferase (ACAT) inhibitors, were determined mainly by spectroscopic studies including various NMR measurements. Pyripyropenes have a common structure which consists of pyridine, α-pyrone and sesquiterpene moieties. One of the three O-acetyl residues in the sesquiterpene moiety of pyripyropene A is replaced with an O-propionyl residue in pyripyropenes B, C and D. © 1994, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.