Abstract
The function of α-synuclein (α-syn) has been long debated, and two seemingly divergent views have emerged. In one, α-syn binds to VAMP2, acting as a SNARE chaperone—but with no effect on neurotransmission—while another posits that α-syn attenuates neurotransmitter release by restricting synaptic vesicle mobilization and recycling. Here, we show that α-syn–VAMP2 interactions are necessary for α-syn–induced synaptic attenuation. Our data connect divergent views and suggest a unified model of α-syn function.
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Sun, J., Wang, L., Bao, H., Premi, S., Das, U., Chapman, E. R., & Roy, S. (2019). Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling. Proceedings of the National Academy of Sciences of the United States of America, 166(23), 11113–11115. https://doi.org/10.1073/pnas.1903049116
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