In the last decade, considerable advancements have been made to identify the pharmacokinetic/pharmacodynamic (PK/PD) index that defines the antimicrobial activity of polymyxins. Dose-fractionation studies performed in hollow-fiber models found that altering the dosing schedule had little impact on the killing or suppression of resistance emergence, alluding to AUC/MIC as the pharmacodynamic index that best describes polymyxin’s activity. For in vivo efficacy, the PK/PD index that was the most predictive of the antibacterial effect of colistin against P. aeruginosa and A. baumannii was ƒAUC/MIC.
CITATION STYLE
Lee, W., Cai, Y., Lim, T. P., Teo, J., Chua, S. C., & Kwa, A. L. H. (2019). In vitro Pharmacodynamics and PK/PD in Animals. In Advances in Experimental Medicine and Biology (Vol. 1145, pp. 105–116). Springer New York LLC. https://doi.org/10.1007/978-3-030-16373-0_8
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