Early death (ED) occurs in 10-30% of patients with acute promyelocytic leukemia (APL). Is all- trans retinoic acid (ATRA) promptly given and does it decrease overall early mortality? ATRA was administered within 24. h of morphological suspicion in only 44% of the 120 consecutive patients treated in the four collaborating centers. Absence of disseminated intravascular coagulation (p= 0.012) and admission to a non-university-affiliated hospital (p= 0.032) were independent predictors of ATRA delay. ED occurred in 17% of patients, and was independently correlated only with ICU admission (p= 0.002). Our results do not demonstrate that prompt (versus delayed) ATRA administration decreases overall early death. © 2014 Elsevier Ltd.
CITATION STYLE
Rashidi, A., Riley, M., Goldin, T. A., Sayedian, F., Bayerl, M. G., Aguilera, N. S., … Fisher, S. I. (2014). Delay in the administration of all-trans retinoic acid and its effects on early mortality in acute promyelocytic leukemia: Final results of a multicentric study in the United States. Leukemia Research, 38(9), 1036–1040. https://doi.org/10.1016/j.leukres.2014.06.011
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