Background/Aim: Nivolumab monotherapy for advanced/metastatic renal cell carcinoma (RCC) shows a survival benefit. The purpose of this study was to evaluate tumor responses to nivolumab in various metastatic and primary sites in patients with RCC. Patients and Methods: We retrospectively reviewed 68 patients who underwent nivolumab monotherapy after one or more regimens of targeted therapy for advanced/metastatic RCC. The site-specific response was evaluated and progression-free survival was estimated. Results: The site-specific overall response rates (ORRs) were as follows: lung (36%), bone (5%), lymph node (33%), liver (50%), adrenal gland (29%), pancreas (33%), and brain (0%). The ORR of bone metastasis was significantly worse in comparison to lung and liver metastases (p=0.017, 0.008). The site-specific median progression-free survival times were as follows: lung (5.1 months), bone (not reached), lymph node (not reached), and liver (17.5 months). Conclusion: Responses to nivolumab may vary depending on metastasized organs.
CITATION STYLE
Negishi, T., Furubayashi, N., Nakagawa, T., Nishiyama, N., Kitamura, H., Hori, Y., … Nakamura, M. (2021). Site-specific response to nivolumab in renal cell carcinoma. Anticancer Research, 41(3), 1539–1545. https://doi.org/10.21873/anticanres.14913
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