S28. ADVERSE CHILDHOOD EXPERIENCES AND PSYCHOTIC-LIKE EXPERIENCES ARE ASSOCIATED ABOVE AND BEYOND SHARED CORRELATES: FINDINGS FROM THE ADOLESCENT AND BRAIN COGNITIVE DEVELOPMENT (ABCD) STUDY

Abstract

Background: Adverse childhood experiences (ACE) are associated with increased risk for schizophrenia spectrum symptoms, including PLEs. However, ACE and PLEs are also both associated with a several shared factors (i.e., stress, fluid cognition, internalizing symptoms, and suicidality). These factors, PLEs, and ACE may interrelate in complex ways, but research has not explicitly examined whether the association between ACE and PLEs remains over and above these shared correlates. This presentation will also examine evidence of PLEs mediating the associated between ACE and stress, fluid cognition, internalizing symptoms, suicidality or vice versus. Clarifying these interrelationships has important clinical implications, including understanding the mechanisms contributing to the development of PLEs and other negative psychopathological correlates. Methods: The current study used hierarchical linear models to examine data from 10,800 9-11-year-olds from the ABCD study, recruited from 21 research sites across the United States. The analyses used hierarchical linear models (HLMs), with family unit and research site modeled as random intercepts, and age, sex, and race/ethnicity included as covariates. Child participants completed the Prodromal Questionnaire-Brief Child Version as a measure of PLEs. The ACE variable was defined as summations of parent-rated child experience of traumatic experiences from the KiddieStructured Assessment for Affective Disorders and Schizophrenia (KSADS) for DSM-5 and a demographic measure of financial adversity. In terms of shared correlates, internalizing symptoms and suicidality were measured using the KSADS, fluid cognition was measured using the NIH Toolbox, and stress was measured using the Child Behavior Checklist. Results: Greater number of ACE were associated with greater PLEs (β=.102; 95% CI=0.083,0.120; p