In this chapter, we give a brief yet self-contained introduction to computational molecular evolution. In particular, we present the emergence of the use of likelihood-based methods, review the standard DNA substitution models, and introduce how model choice operates. We also present recent developments in inferring absolute dates and rates on a phylogeny and show how state-of-the-art models take inspiration from diffusion theory to link population genetics, which traditionally focuses at a taxonomic level under that of species, and molecular evolution. © 2012 Springer Science+Business Media, LLC.
CITATION STYLE
Aris-Brosou, S., & Rodrigue, N. (2012). The essentials of computational molecular evolution. Methods in Molecular Biology, 855, 111–152. https://doi.org/10.1007/978-1-61779-582-4_4
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