This morphometric study examined two aspects of corpus callosum development: pediatric cortico-cullosal topography and developmental neuroplasticity subsequent to perinatal brain injury. In vivo magnetic resonance imaging was used to quantify the total midsagittal cross-sectional area and five antorioposterior subregions of the callosum in 10 children with focal lesions and 86 healthy volunteer control subjects. Nine of the ten children with early injury showed u reduction in the total area of the callosum relative to matched controls. The area of the total callosum cross-section was inversely proportional to the size of lesion. All patients displayed region-specific size reduction. This regional thinning bore a topographical relationship to the lesion sites. Reduction in anterior subregions 1, 2 and 3 was respectively associated with lesions in the anterior inferior frontal area, the middle and superior frontal region, and the precentral area. Attenuation of subregion 4 corresponded to anterior parietal lesions, and thinning of subregion 5 occurred with posterior parietal injury. This cortical-callosal pattern coincides with adult and nonhuman primate mappings. Callosal thinning despite the early onset of the lesions suggests limits to developmental neuroplasticity.
CITATION STYLE
Moses, P., Courchesne, E., Stiles, J., Trauner, D., Egaas, B., & Edwards, E. (2000). Regional size reduction in the human Corpus callosum following pre- and perinatal brain injury. Cerebral Cortex, 10(12), 1200–1210. https://doi.org/10.1093/cercor/10.12.1200
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