Regional size reduction in the human Corpus callosum following pre- and perinatal brain injury

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Abstract

This morphometric study examined two aspects of corpus callosum development: pediatric cortico-cullosal topography and developmental neuroplasticity subsequent to perinatal brain injury. In vivo magnetic resonance imaging was used to quantify the total midsagittal cross-sectional area and five antorioposterior subregions of the callosum in 10 children with focal lesions and 86 healthy volunteer control subjects. Nine of the ten children with early injury showed u reduction in the total area of the callosum relative to matched controls. The area of the total callosum cross-section was inversely proportional to the size of lesion. All patients displayed region-specific size reduction. This regional thinning bore a topographical relationship to the lesion sites. Reduction in anterior subregions 1, 2 and 3 was respectively associated with lesions in the anterior inferior frontal area, the middle and superior frontal region, and the precentral area. Attenuation of subregion 4 corresponded to anterior parietal lesions, and thinning of subregion 5 occurred with posterior parietal injury. This cortical-callosal pattern coincides with adult and nonhuman primate mappings. Callosal thinning despite the early onset of the lesions suggests limits to developmental neuroplasticity.

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APA

Moses, P., Courchesne, E., Stiles, J., Trauner, D., Egaas, B., & Edwards, E. (2000). Regional size reduction in the human Corpus callosum following pre- and perinatal brain injury. Cerebral Cortex, 10(12), 1200–1210. https://doi.org/10.1093/cercor/10.12.1200

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