Endophytic fungi has been known as a source of biologically active compunds with a broad sprectrum of activities. One of the endophytic fungi isolated from young stem of gambier plant ( Uncaria gambier Roxb.:Rubiaceae), Diaporthe sp. GNBP-10, produced (+)-1,1’-bislunatin when cultivated on potato dextrose agar (PDA). (+)-1,1’-Bislunatin showed moderate antibacterial activity against 7 bacteria ( Bacillus subtilis , Staphylococcus aureus , Escherichia coli , Micrococcus luteus , Shigella flexneri , Proteus vulgaris , and P. mirabilis ) with MIC value in the range of 32-64 µg mL -1 . The wall disruption and morphological changes in the cells affected by exposure of (+)-1,1’-bislunatin are also discussed in this article.
PRAPTIWI, P., JAMAL, Y., FATHONI, A., NURKANTO, A., & AGUSTA, A. (2013). Antibacterial Activity of Bisanthraquinone (+)-1,1’-Bislunatin. Microbiology Indonesia, 7(4), 159–166. https://doi.org/10.5454/mi.7.4.4