INHIBITION OF HYPOXIC PULMONARY VASOCONSTRICTION BY HYPOXIC EXERCISE TRAINING IN RATS

Abstract

This study reviewed the influence of hypoxic training on hypoxicpulmonary vasoconstriction (HPV) sensitivity in the isolated perfusedlungs preparation of rats. In addition, the study examined the kind ofmechanism involved. Therefore, we inhibited nitric oxide (NO) release ofendothelial cells, using on NO synthase inhibitor. and reviewed theimpact on HPV.As a result, the following became clear. 1) Hypoxic training inhibitedHPV. 2) HPV was increased by the administration of NO synthase inhibitorL-NMMA, in particular, conspicuously inhibited HPV in the hypoxictraining group was increased. 3) The negative correlation between theonset of blood lactate accumulation and HPV was significant.From the above. it can be concluded that hypoxic training inhibited HPVand NO release for a pulmonary vascular endothelial cell In addition, weunderstood that HPV was decreased by hypoxic training as the ability forendurance exercise was increased.