Humane endpoints for genetically engineered animal models

Abstract

Genetic engineering studies are increasing and they offer an exciting tool for the study of disease processes. Due to the discovery nature of many of these studies, it is difficult to predict the outcomes of the genetic manipulations planned. The result can be creation of new lines of animals with debilitating phenotypes. It is crucial for institutions to supervise and continually review the studies to indentify problems as they occur and to ensure that appropriate, humane end-points are established. When identified, there are some novel strategies that can be attempted to resolve or minimize the impact of porblems on compromised animals. Successful resolution of welfare concerns may be achieved when the PI, attending veterinarian, and IACUC members cooperate.