Linear free energy relationships of the 13C NMR chemical shifts in 5-(3-and 4-substituted arylazo)-4,6-dimethyl-3-cyano-2-pyridones

Abstract

The 13C NMR chemical shifts of the C2 carbon atom in the heteroaromatic nuclei of seventeen 5-(3-and 4-substituted arylazo)-4,6-dimethyl- 3-cyano-2-pyridones were determined in deuterated DMSO solution. For quantitative assessment of the substituent effects on the 13C NMR chemical shifts simple and extended Hammett equations and Swain-Lupton equation were used. The mode of transmission of substituent effects have been discussed in a relation to the geometry of investigated molecules. The geometry data were obtained using semiempirical MNDO-PM6 energy calculations. The observed 13C NMR substituent chemical shifts were correlated with literature 13C NMR data for the corresponding 3-and 4-substituted-2',6'- dimethylazobenzenes and 3-and 4-substituted azobenzenes. A good linear dependence obtained in this way, provided a basis to discuss the influence of the ortho-methyl groups on the degree of coplanarity of azobenzene and pyridone systems, and on the efficiency of transmission of electronic substituent effect from one ring to the other one. © ARKAT USA, Inc.