Abstract
The exquisite selectivity of chemical reactions enables the study of rare DNA bases. However, chemical modification of the genome can affect downstream analysis. We report a PCR bias caused by such modification, and exemplify a solution with the synthesis and characterization of a cleavable aldehyde-reactive biotinylation probe. © 2014 The Partner Organisations.
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CITATION STYLE
APA
McInroy, G. R., Raiber, E. A., & Balasubramanian, S. (2014). Chemical biology of genomic DNA: minimizing PCR bias. Chemical Communications, 50(81), 12047–12049. https://doi.org/10.1039/c4cc05107f
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