Two polymorphic aval and HhaI sites in a differentially methylated region of the human H19 gene

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Abstract

The H19 gene is paternally imprinted both in the human and mouse (Bartolomei et oJ., 1991; Zhang and Tycko, 1992), although its expression pattern seems somewhat different between the two species (Jinno et al, 1995). DNA-methylation is a promising candidate for a parent-of-origin mark of the gene, and a paternal allele-specific methylation imprint was recently identified at the mouse H19 locus (Tremblay et ai, 1995). We found a 50% methylated region in the human H19 gene (Jinno, unpublished data). A search for polymorphisms in this region revealed two novel Aval and Hha\ RFLPs, which contribute to the detection of allele-specific methylation at the human H19 locus.

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Miyatake, S., Ikeda, Y., Jinno, Y., & Niikawa, N. (1996). Two polymorphic aval and HhaI sites in a differentially methylated region of the human H19 gene. Japanese Journal of Human Genetics, 41(2), 253–255. https://doi.org/10.1007/BF01875986

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