Recruitment of skeletal muscle progenitors to secondary sites: A role for CXCR4/SDF-1 signalling in skeletal muscle development

Abstract

During embryonic development, myogenesis occurs in different functional muscle groups at different time points depending on the availability of their final destinations. Primary trunk muscle consists of the intrinsic dorsal (M. erector spinae) and ventral (cervical, thoracic, abdominal) muscles. In contrast, secondary trunk muscles are established from progenitor cells that have migrated initially from the somites into the limb buds and thereafter returned to the trunk. Furthermore, craniofacial muscle constitutes a group that originates from four different sources and employs a different set of regulatory molecules. Development of muscle groups at a distance from their origins involves the maintenance of a pool of progenitor cells capable of proliferation and directed cell migration. We review here the data concerning somite-derived progenitor cell migration to the limbs and subsequent retrograde migration in the establishment of secondary trunk muscle in chicken and mouse. We review the function of SDF-1 and CXCR4 in the control of this process referring to our previous work in shoulder muscle and cloacal/perineal muscle development. Some human anatomical variations and malformations of secondary trunk muscles are discussed.