Synthesis and anti-inflammatory activity of 3-indolyl pyridine derivatives through one-pot multi component reaction

Abstract

A simple protocol for the efficient preparation of 2-(1H-Indol-3-yl)-6- methoxy-4-arylpyridine-3,5-dicarbonitrile has been achieved through one-pot multi-component reaction under reflux condition. These compounds showed a good anti-inflammatory activity. Also a series of bis-Hantzsch dihydropyridine derivatives were synthesized and they exhibit analgesic activity. © Indian Academy of Sciences.