Evolutionary relationships between the laccase genes of polyporales: Orthology-based classification of laccase isozymes and functional insight from trametes hirsuta

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Abstract

Laccase is one of the oldest known and intensively studied fungal enzymes capable of oxidizing recalcitrant lignin-resembling phenolic compounds. It is currently well established that fungal genomes almost always contain several non-allelic copies of laccase genes (laccase multigene families); nevertheless, many aspects of laccase multigenicity, for example, their precise biological functions or evolutionary relationships, are mostly unknown. Here, we present a detailed evolutionary analysis of the sensu stricto laccase genes (CAZy - AA1_1) from fungi of the Polyporales order. The conducted analysis provides a better understanding of the Polyporales laccase multigenicity and allows for the systemization of the individual features of different laccase isozymes. In addition, we provide a comparison of the biochemical and catalytic properties of the four laccase isozymes from Trametes hirsuta and suggest their functional diversification within the multigene family.

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Savinova, O. S., Moiseenko, K. V., Vavilova, E. A., Chulkin, A. M., Fedorova, T. V., Tyazhelova, T. V., & Vasina, D. V. (2019). Evolutionary relationships between the laccase genes of polyporales: Orthology-based classification of laccase isozymes and functional insight from trametes hirsuta. Frontiers in Microbiology, 10(FEB). https://doi.org/10.3389/fmicb.2019.00152

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