Efficient Referencing of FSLG CPMAS HETCOR Spectra Using 2D 1H–1H MAS FSLG

Abstract

FSLG CPMAS HETCOR is a 2D solid-state NMR experiment which provides structural information and conformational correlation between a 1H and an X-nucleus. However, practical application of the experiment suffers from the chemical shift referencing problem on the indirect 1H dimension. In our paper, we present a novel 1H–1H MAS FSLG-based approach and its application to reference the FSLG CPMAS HETCOR which overcomes the 1H referencing in the 2D 1H-X HETCOR experiment. This approach works excellently irrespective of the sample type over a wide range of temperature.