Pump-probe microscopy non-destructively differentiates eumelanin and pheomelanin and can be used to quantify melanin distributions in thin biopsy slices. Here we have extended that work for imaging eumelanin and pheomelanin distributions on a sub-cellular scale, allowing elucidation of characteristics of different cell types. The results show that melanin heterogeneity, previously found to be characteristic of melanomas, persists on the sub-cellular scale. We have also found spectral changes associated with melanin located in melanophages, which could potentially differentiate invasive pigmented melanocytes from melanophages without immunohistochemical staining.
CITATION STYLE
Orlik, P., & Welker, V. (2007). Cellular Resolution. In Algebraic Combinatorics (pp. 125–144). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-68376-6_6
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