It was hypothesized that, following effective initial vaccination, a booster dose of hepatitis B vaccine will not be necessary in areas of hyperendemicity for hepatitis B virus (HBV) infection. A total of 314 Ethiopian children, ranging from two to 14 years old, were alternatively vaccinated with 10 and 20 μg hepatitis B vaccine doses, using the initial, one- and six-month schedule. Five years later, 210 of the vaccinees were retested for anti-HBV surface antibody titres. Both 10 and 20 μg doses of hepatitis B rDNA yeast vaccine were equally immunogenic and protective against HBV infection for at least five years despite marked reduction of mean antibody levels and geometric mean titres, with 11% of the vaccinees showing antibodies below the protective level. For firm further recommendations a longer follow-up period of vaccinees is suggested.
CITATION STYLE
Tsega, E., Horton, J., Nordenfelt, E., Hansson, B. J., Tafesse, B., Wolde-Hawariat, G., & Lindberg, J. (1998). Antibody levels in Ethiopian children five years after vaccination with two different doses of hepatitis B vaccine: Is there a need for booster vaccine? Canadian Journal of Gastroenterology, 12(1), 57–60. https://doi.org/10.1155/1998/213028
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