Animal Models of Obsessive-Compulsive Disorder: Strain Differences

Abstract

Obsessive-compulsive\rdisorder (OCD) is characterized by obsessions (intrusive thoughts, images etc.)\rand compulsions (repetitive, stereotyped and perseverant acts). Animal models\rof OCD are specifically devoted to simulating compulsive features of the\rdisorder. In OCD, compulsive behaviors are recognized as repetitive and\rmaladaptive and symptoms relief can be experienced due to treatment with\rselective serotonin reuptake inhibitors. Many animal models of OCD are provided\rwith some degree of validity. Genetically based differences in behavior in\ranimal models of OCD are of great value, given that human OCD is reported to\rinvolve genetic factors. Some animal models of OCD were already used in studies\rfor the evaluation of strain differences. These works were explored in the\rpresent review.