Response surface methodology (RSM) was applied to predict optimum conditions for extraction of flavonoid from Coreopsis tinctoria Nutt. A central composite design (CCD) was used to monitor the effect of extraction temperature, extraction time, and water-to-material ratio on yield of total flavonoids. The optimal extraction conditions were obtained as water-to-material ratio of 55 ml g-1, extraction temperature of 80 °C and extraction time of 70 minutes. Under these conditions, the average total flavonoids yield, according to the mass of raw material, was 9.0 ± 0.6%, which corresponds to the predicted value of 8.9%. Thus, the extraction method was applied successfully to extract total flavonoids from C. tinctoria.
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Liu, X. F., Liu, L., Wang, Y. G., & Leng, F. F. (2014). Optimization of total flavonoids extraction from coreopsis tinctoria nutt. by response surface methodology. Kemija u Industriji/Journal of Chemists and Chemical Engineers, 63(11–12), 391–396. https://doi.org/10.15255/KUI.2013.027