A review of the potential therapeutic role of statins in the treatment of alzheimer's disease: Current research and opinion

Abstract

Alzheimer's disease is one of the most prevalent neurodegenerative disorders. However, there is no current treatment, which definitively influences disease progression over a sustained period. Numerous studies linking an increase in serum cholesterol, mainly during midlife, with the pathogenic process of Alzheimer's disease have been published. Therefore, the role of statins as a therapy in this disorder may be of great interest. The aim of the present review is to summarize of the role of statins in the treatment of Alzheimer's disease. Keywords: animal models, epidemiology, HMGCoA-inhibitors, clinical trials, prevention, cognitive function. © 2013 Sánchez-Ferro et al, publisher and licensee Dove Medical Press Ltd.