Antibacterial activity of diphenyltin(IV) and triphenyltin(IV) 3-chlorobenzoate againts Pseudomonas aeruginosa and Bacillus subtilis

Abstract

In this paper, we reported the syntheses and antibacterial activity test of 2 organotin(IV) compounds, diphenyltin (IV) di-3-chlorobenzoate (2) and triphenyltin (IV) 3-chlorobenzoate (4). These two compounds were prepared by the reaction of diphenyltin (IV) dihydroxide and triphenyltin (IV) hydroxide with 3-chlorobenzoic acid. These compounds were characterized by 1H and 13C NMR, IR, UV-Vis spectroscopies and also based on the microanalytical data. The results of antibacterial activity by diffusion method against Pseudomonas aeruginosa and Bacillus subtilis showed that the triphenyltin(IV) 3-chlorobenzoate was active at concentration of 3.956 x 10-4M (200 ppm), while the chloramphenicol gave inhibition of 6.1894 x 10-4 M (200 ppm), although the halozone was bigger. This result indicated that compound 4 is potentially to be used as antibacterial substance, although the search of other derivative of organotin (IV) with other ligands is still needed to get much higher and much better activity.