Male accessory gland infections (MAGI) are included among the conventional diagnostic categories recognized to cause male infertility. They constitute a clinical model of oxidative stress for a number of considerations: (a) some uropathogens or etiological agents of sexually transmitted diseases ( Chlamydia trachomatis, Ureaplasma urealyticum ) by themselves, microbial products, and/or toxic metabolites may contribute to an overproduction of reactive oxygen species (ROS); (b) the canalicular spread of pathogens to one or more male accessory glands causes a further increase of ROS production, since they become the site of infl ammation as shown by the presence of morphostructural abnormalities. The infecting pathogen triggers an infl ammatory process which includes a series of multiple persistent components, such as kinetic of leukocyte subpopulations, pattern of cytokine production, and morphostructural abnormalities of the infected glands. This results in a final impairment of conventional and nonconventional sperm parameters. Therefore, MAGI-related oxidative stress is the sum of a microenvironmental and sperm-related damage. This includes several redox imbalance in the gland (ratio of gland infl amed areas to noninfl amed areas), pattern of cytokine release (prooxidative/antioxidant ratio), and sperm microenvironment.
CITATION STYLE
Vicari, E., La Vignera, S., & Calogero, A. E. (2012). Oxidative stress and infection. In Studies on Men’s Health and Fertility (pp. 551–570). Humana Press Inc. https://doi.org/10.1007/978-1-61779-776-7_25
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