Organometallic complexes offer potential for design as anticancer drugs. They can act as inert scaffolds and specifically inhibit enzymes such as kinases, or as pro-drugs which undergo activation by various mechanisms. The activation of metallocenes, arene, alkyl or aryl complexes by hydrolysis, and metal- or ligand-based redox reactions is discussed. © 2010 Springer-Verlag Berlin Heidelberg.
CITATION STYLE
Pizarro, A. M., Habtemariam, A., & Sadler, P. J. (2010). Activation mechanisms for organometallic anticancer complexes. Topics in Organometallic Chemistry, 32, 21–56. https://doi.org/10.1007/978-3-642-13185-1_2
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