First attempt at 3D X-ray visualization of DCIS (Ductal Carcinoma in Situ) due to refraction contrast - In good relation to pathological view

Abstract

First 3D X-ray internal observation of DCIS (ductal carcinoma in-situ) is reported. Its rod shaped specimen with 3.6 mm in diameter and 4.7 mm in height was punched out to have successfully observed by using a newly made algorithm due to refraction for x-ray CT. Its data was acquired by the x-ray optics DEI (diffraction-enhanced imaging). Data of 900 projections with interval of 0.2 degrees was used at Photon Factory, KEK in Tsukuba. A reconstructed CT image may include clearly revealed ductus lactiferi, microcalcification and other structure. The voxel resolution is approximately 50 μm by the present instrumental condition. This modality could open up an x-ray pathological diagnosis. © Springer-Verlag Berlin Heidelberg 2006.