The Giant Protein Titin

  • Granzier H
  • Labeit S
N/ACitations
Citations of this article
13Readers
Mendeley users who have this article in their library.

Abstract

The sarcomere contains, in addition to thin and thick filaments, a filament composed of the giant protein titin (also known as connectin). Titin molecules anchor in the Z-disc and extend to the M-line region of the sarcomere. The majority of titin’s I-band region functions as a molecular spring. This spring maintains the precise structural arrangement of thick and thin filaments, and gives rise to passive muscle stiffness; an important determinant of diastolic filling. Earlier work on titin has been reviewed before. In this study, our main focus is on recent findings vis-à-vis titin’s molecular spring segments in cardiac titins, including the discovery of fetal cardiac isoforms with novel spring elements. We also discuss new insights regarding the role of titin as a biomechanical sensor and signaling molecule. We will end with focusing on the rapidly growing knowledge regarding titinopathies.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Granzier, H. L., & Labeit, S. (2004). The Giant Protein Titin. Circulation Research, 94(3), 284–295. https://doi.org/10.1161/01.res.0000117769.88862.f8

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 5

56%

Researcher 4

44%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 4

50%

Medicine and Dentistry 2

25%

Materials Science 1

13%

Engineering 1

13%

Article Metrics

Tooltip
Mentions
News Mentions: 3

Save time finding and organizing research with Mendeley

Sign up for free