We examined the relation with birth weight and umbilical cord blood concentrations of haematopoietic stem and progenitor populations in 288 singleton infants. Across the whole range of birth weight, there was a positive relation between birth weight and CD34+CD38- cells, with each 500 g increase in birth weight being associated with a 15.5% higher (95% confidence interval: 1.6-31.3%) cell concentration. CD34+ and CD34+c-kit+ cells had J-shaped relations and CFU-GM cells had a U-shaped relation with birth weight. Among newborns with ≥3000 g birth weights, concentrations of these cells increased with birth weight, while those below 3000 g had higher stem cell concentrations than the reference category of 3000-3499 g. Adjustment for cord blood plasma insulin-like growth factor-1 levels weakened the stem and progenitor cell-birth weight associations. The positive associations between birth weight and stem cell measurements for term newborns with a normal-to-high birth weight support the stem cell burden hypothesis of cancer risk. © 2008 Cancer Research UK.
CITATION STYLE
Strohsnitter, W. C., Savarese, T. M., Low, H. P., Chelmow, D. P., Lagiou, P., Lambe, M., … Hsieh, C. C. (2008). Correlation of umbilical cord blood haematopoietic stem and progenitor cell levels with birth weight: Implications for a prenatal influence on cancer risk. British Journal of Cancer, 98(3), 660–663. https://doi.org/10.1038/sj.bjc.6604183
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