The contribution of the sodium-calcium exchanger (NCX) and plasma membrane Ca2+ ATPase (PMCA) to cerebellar synapse function

Abstract

The cerebellum, a part of the brain critically involved in motor learning and sensory adaptation, expresses high levels of the sodium-calcium exchanger (NCX) and the plasma membrane calcium ATPase (PMCA). Both these transporters control calcium dynamics at a variety of synapses, and here, we draw upon the available literature to discuss how NCX and PMCA work together to shape pre-synaptic calcium dynamics at cerebellar synapses. © Springer Science+Business Media New York 2013.