The impact of hyperthermal surfaces on blood in vitro - An approach

Abstract

The influence of heat dissipating systems, such as blood pumps, was investigated. Titanium cylinders as blood pump housing dummies were immersed in porcine blood and constantly tempered at specific temperatures (37°C - 60°C) over a defined period of time. The porcine blood was anticoagulated either by low heparin dosage or citrate. At frequent intervals, samples were taken for blood analysis and the determination of the plasmatic coagulation cascade. Blood parameters do not alter at surface temperatures below 50°C. The plasmatic coagulation cascade is terminated at surface temperatures exceeding 55°C. The adhesion of blood constituents on surfaces is temperature and time dependent and structural changes of adhesions and blood itself were detected. © 2009 Springer-Verlag.