The Effect of Gene Mutations on Metastasis and Overall Survival in Metastatic and Nonmetastatic Colon Cancers

Abstract

Objective: It is known that many genes are associated with colon cancer. We aimed to investigate the effect of gene mutations on metastasis and overall survival in metastatic and non metastatic colon cancers. Methods: A total of 50patients with metastatic (n=25) and non metastatic (n=25) diagnosed with colon cancer between 2010 and 2018 wereincluded in the study. APC, MUTYH, RAD50, MEN1, ATM, PALB2, NSH2, BRCA1, BRCA2, MLH1, BRIP1, TP53,PTEN, BARD1, MSH6, PMS2, NBN, and FAM175A gene mutations were evaluated using the next generation sequencingmethod. The effect of gene mutations on metastasis and overall survival were evaluated. Results: The mean age ofpatients with colon cancer without distant metastasis was 48.64±14.72 years and for patients with distance metases was56.68±11.65. The mean survival time of colon cancer patients with distant organ metastasis after the metastasis datewas 104.36±58.59 weeks. The presence of APC, MUTYH, and TP53 genetic mutations was observed with a higher ratein metastatic colon cancer (p<0.05). Conclusion: We showed that APC, MUTYH, and TP53 mutations are associatedwith distant organ metastasis