Catalytic one-pot synthesis of 4-(hetero)aryl substituted 5-(2-oxoethyl) oxazol-2(3: H)-ones by coupling-isomerization-elimination (CIE) sequence

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Abstract

N-Boc protected 1-aryl propargyl carbamates and acid chlorides can be readily transformed in a one-pot fashion by a coupling-isomerization-elimination (CIE) sequence into 4-substituted 5-(2-oxoethyl) oxazol-2(3H)-ones in moderate to good yield.

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Görgen Née Boersch, C., Lutsenko, K., Merkul, E., Frank, W., & Müller, T. J. J. (2016). Catalytic one-pot synthesis of 4-(hetero)aryl substituted 5-(2-oxoethyl) oxazol-2(3: H)-ones by coupling-isomerization-elimination (CIE) sequence. Organic Chemistry Frontiers, 3(7), 887–896. https://doi.org/10.1039/c6qo00138f

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