Abstract
EI-1507-1 and -2, novel interleukin-1β converting enzyme (ICE) inhibitors, were isolated from the culture broths of Streptomyces sp. E-1507, EI-1507-1 and EI-1507-2 selectively inhibited the recombinant human ICE activity with IC50 values of 0.23 and 0.42 μM, respectively. EI-1507-1 and EI-1507-2 also inhibited mature interleukin-1β secretion from THP-1 cells with IC50 values of 1.1 and 1.4 μM, respectively.
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CITATION STYLE
Tsukuda, E., Tanaka, T., Ochiai, K., Kondo, H., Yoshida, M., Agatsuma, T., … Matsuda, Y. (1996). EI-1507-1 and -2, novel interleukin-1β converting enzyme inhibitors produced by Streptomyces sp. E-1507. Journal of Antibiotics, 49(4), 333–339. https://doi.org/10.7164/antibiotics.49.333
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