Silicone binding immunoglobulins in human sera

Abstract

We have evaluated two recently published test procedures for demonstrating antibodies to silicone. Positive control serum samples provided to us by the original authors were positive in our hands, using the methods described. However, serum samples from patients with certain connective tissue diseases but no history of silicone implants were also positive. The question of silicone-specific antibodies remains unresolved.