Involvement of CD147 isoform-4 in the proliferation of SiHa cells: A possible molecular mechanism of cervical cancer

Abstract

CD147, a multifunction glycoprotein of the immunoglobulin family, is associated with many types of tumors, and the overexpression of CD147 can enhance malignancy. However, the role of CD147 in cervical cancer remains unclear. In the present study, cervical cancer cells were found to express much more CD147 protein and isoform-4 than normal cervical cells (P<0.05), suggesting that CD147 and isoform-4 are involved in cervical cancers. Furthermore, we overexpressed the CD147 isoform-4 (CD147-4) in the cervical cancer cell line SiHa by transfection and found that CD147-4 promoted the proliferation of SiHa cells with a considerable proportion of cells in the S phase in which the expression of CIP2A, PLK and cyclin D1 was up-regulated while the expression of P27 was down-regulated. This may be one of the molecular mechanisms involved in cervical cancer progression by CD147.