Primary Burkitt's lymphoma of the thyroid without Epstein-Barr virus infection: A case report and literature review

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Abstract

Primary thyroid lymphomas are rare, and the majority are B-cell lymphoma. Primary Burkitt's lymphoma (BL) of the thyroid is much less common than the other types of lymphoma. The current study presents the case of an eight-year-old male with a mass in the right lobe of the thyroid, which was detected by B-ultrasound. The patient was diagnosed with BL by immunohistochemistry, fluorescence in situ hybridization analysis of MYC (8q24) and immunoglobulin rearrangement assays. Furthermore, subsequent positron emission tomography-computed tomography scans revealed no abnormal metabolites in the left lobe of the thyroid or in other parts of the body following surgery. The patient underwent alternate R-B-NHL-BFM-90-A and R-B-NHL-BFM-90-B treatment for four cycles each following the thyroidectomy. The patient is well and remains free of disease recurrence following almost four years follow-up. The present study discusses this rare case of primary BL of the thyroid and presents a review of the literature. This case report provides evidence that the immediate diagnosis and treatment of primary Burkitt's lymphoma of the thyroid is likely to improve patient outcome.

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APA

Zhang, L., Gao, L., Liu, G., Wang, L., Xu, C., Li, L., … Guo, Z. (2014). Primary Burkitt’s lymphoma of the thyroid without Epstein-Barr virus infection: A case report and literature review. Oncology Letters, 7(5), 1519–1524. https://doi.org/10.3892/ol.2014.1941

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