Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory condition with increasing incidence and prevalence around the world. Although B cells had generally been believed to play a pathogenic role in IBD due to the production of autoantibodies, a growing body of evidence from mouse models suggests the coexistence of pathogenic B cells and regulatory B cells, termed Breg, in this disorder. Since some unique techniques are required to closely study the Breg in gut-associated lymphoid tissues (GALT), we herein describe how to induce colitis in mice and how to analyze the phenotype and function of GALT-specific Breg. © 2014 Springer Science+Business Media New York.
CITATION STYLE
Nishida, A., Lau, C. W., Mizoguchi, E., & Mizoguchi, A. (2014). Regulatory B cells in mouse models of intestinal inflammation. Methods in Molecular Biology, 1190, 227–241. https://doi.org/10.1007/978-1-4939-1161-5_16
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