Controlled reactive intermediates enabling facile molecular conjugation

Abstract

Reliable methods to conjugate molecules using highly reactive substrates including strained cycloalkynes, azides, and thiophene S, S-dioxides, or short-lived intermediates such as arynes and 6- and 7-membered cycloalkynes have been developed. This account describes our recent achievement on the development of facile methods conjugating a wide variety of molecules based on the reactivity of controlled short-lived intermediates.