Semen parameters after SARS-CoV-2 infection: A literature review

Abstract

Background and Aims: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to affect multiple organs by binding to angiotensin-converting enzyme 2 receptors and might therefore affect male fertility. This review aims to collect all original articles on the effects of SARS-CoV-2 infection on male fertility, including the duration of time after infection required for these effects to begin to manifest and recommend how clinicians should approach cases with a recent illness. Methods: This review was developed according to the preferred reporting items for systematic reviews and meta-analyses guidelines. The search string was applied to four online databases—namely Pubmed, Embase, Medline, and the Cochrane COVID-19 Register—and screened using the online tool Covidence.org. Articles were eligible for inclusion if they were cohort studies involving a healthy male population diagnosed with COVID-19, each of whom had semen samples collected before and after the infection or two different semen samples collected after the diagnosis. Results: Nine cohort studies were eventually included. Five articles had pre- and post-COVID-19 data while four had two sets of post-COVID-19 data. The three largest studies found a statistically significant decrease in all semen parameters when waiting less than 3 months from diagnosis before sample collection, and no significant differences in results when the ejaculate was analyzed more than 3 months after recovery. One study compared the COVID-19 patients with a control group and found a significant decrease in semen parameters in the COVID-19 group. Conclusion: Spermatogenesis seems to be affected by SARS-CoV-2 infection, but the impact tends to reverse within 3–4 months. It is still unclear why male fertility is affected by SARS-CoV-2 infection, and it might be the result of several different components. Clinicians should consider recent SARS-CoV-2 infection as a possible reason for the low semen quality of patients' semen samples, and might therefore need to collect new samples after 4 months before further treatment.