Gene regulation arises out of dynamic competition between nucleosomes, transcription factors, and other chromatin proteins for the opportunity to bind genomic DNA. The timescales of nucleosome assembly and binding of factors to DNA determine the outcomes of this competition at any given locus. Here, we review how these properties of chromatin proteins and the interplay between the dynamics of different factors are critical for gene regulation. We discuss how molecular structures of large chromatin-associated complexes, kinetic measurements, and high resolution mapping of protein-DNA complexes in vivo set the boundary conditions for chromatin dynamics, leading to models of how the steady state behaviors of regulatory elements arise.
CITATION STYLE
Ahmad, K., Henikoff, S., & Ramachandran, S. (2022). Managing the Steady State Chromatin Landscape by Nucleosome Dynamics. Annual Review of Biochemistry. Annual Reviews Inc. https://doi.org/10.1146/annurev-biochem-032620-104508
Mendeley helps you to discover research relevant for your work.