Is unexplained elevated maternal serum alpha-fetoprotein still important predictor for adverse pregnancy outcome?

14Citations
Citations of this article
74Readers
Mendeley users who have this article in their library.

Abstract

Objectives: The purpose of this study was to determined the predictive value of maternal serum alpha-fetoprotein (MSAFP) as a marker for adverse pregnancy outcomes. Material and methods: This study was carried out at Dr. Zekai Tahir Burak Women's Health Education and Research Hospital between 2009 and 2010. This study included a total of 1,177 pregnant women, including 170 in the study group and 1,007 in the control group. Pregnancy outcomes and characteristics were analyzed with regard to the MSAFP value. Results: Gestational week, birth weight and APGAR scores were significantly lower in the elevated MSAFP group (p < 0.001). Adverse pregnancy outcomes, such as preterm delivery, preterm premature rupture of membranes (PPROM), oligohydramnios and intrauterine growth restriction (IUGR) rates were increased in the elevated MSAFP group. Conclusions: Although ultrasound outweighs as a screening method for neural tube defects and non-invasive prenatal testing outweighs for aneuploidy screening MSAFP level in the second trimester is still an important predictor for poor maternal/fetal outcomes.

References Powered by Scopus

Pregnancy-associated plasma protein A and alpha-fetoprotein and prediction of adverse perinatal outcome

131Citations
N/AReaders
Get full text

The association between maternal serum alpha-fetoprotein and preterm birth, small for gestational age infants, preeclampsia, and placental complications

120Citations
N/AReaders
Get full text

Serum screening with Down's syndrome markers to predict pre-eclampsia and small for gestational age: Systematic review and meta-analysis

99Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Quad test for fetal aneuploidy screening as a predictor of small-for-gestational age fetuses: a population-based study

16Citations
N/AReaders
Get full text

First-trimester maternal serum alpha-fetoprotein is not a good predictor for adverse pregnancy outcomes: A retrospective study of 3325 cases

11Citations
N/AReaders
Get full text

Imaging findings in association with altered maternal alpha-fetoprotein levels during pregnancy

7Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Başbuğ, D., Başbuğ, A., & Gülerman, C. (2017). Is unexplained elevated maternal serum alpha-fetoprotein still important predictor for adverse pregnancy outcome? Ginekologia Polska, 88(6), 325–330. https://doi.org/10.5603/GP.a2017.0061

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 14

67%

Researcher 6

29%

Lecturer / Post doc 1

5%

Readers' Discipline

Tooltip

Medicine and Dentistry 22

59%

Nursing and Health Professions 10

27%

Biochemistry, Genetics and Molecular Bi... 4

11%

Agricultural and Biological Sciences 1

3%

Save time finding and organizing research with Mendeley

Sign up for free