Analysis of amphetamine and congeners in illicit samples by liquid chromatography and capillary electrophoresis

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Abstract

Screening methods based on liquid chromatography (HPLC) and capillary electrophoresis (CE) have been developed for the identification and determination of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, and 3,4-methylenedioxyethylamphetamine in illicit tablets. Diethylpropione, (-)-ephedrine, and 3-amino-1-phenylbutane were also included in the study as amphetamino-related compounds. The HPLC-diode-array detection method involved on-line photochemical derivatization to enhance the selectivity of detection allowing amphetamines to be distinguished from related compounds such as diethylpropione (amfepramone). When the CE approach was adopted, two identification parameters (UV spectra and migration index) were used and the enantioresolution of the racemic amphetamines was achieved using hydroxypropyl-β-cyclodextrin as chiral selector.

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Di Pietra, A. M., Gotti, R., Del Borrello, E., Pomponio, R., & Cavrini, V. (2001). Analysis of amphetamine and congeners in illicit samples by liquid chromatography and capillary electrophoresis. Journal of Analytical Toxicology, 25(2), 99–105. https://doi.org/10.1093/jat/25.2.99

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