Objective: Refractory status epilepticus is one of the most life-threatening neurological emergencies and is characterized by high morbidity and mortality. Additionally, the use of anti-inflammatory drugs during this period is very controversial. Thus, this study has been designed to analyze the effect of a low dose of indomethacin (a COX inhibitor) on the expression of inflammatory molecules. Method: The hippocampus of rats submitted to pilocarpine-induced long-lasting status epilepticus was analyzed to determine the expression of inflammatory molecules with RT-PCR and immunohistochemistry. Results: Compared with controls, reduced levels of the kinin B2 receptors IL1β and TNFα were found in the hippocampus of rats submitted to long-lasting status epilepticus and treated with indomethacin. Conclusions: These data show that low doses of indomethacin could be employed to minimize inflammation during long-lasting status epilepticus.
CITATION STYLE
Vieira, M. J., Perosa, S. R., Argañaraz, G. A., Silva, J. A., Cavalheiro, E. A., & da Graça Naffah-Mazzacoratti, M. (2014). Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus. Clinics, 69(9), 621–626. https://doi.org/10.6061/clinics/2014(09)08
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