The importance of VERIFI (“Vasomotoric Elimination And Reconstructed Identification of the Initial set-point”) for the performance of the CNAP technology

Abstract

The mechanisms implemented in CNSystems' Continuous Non-invasive Arterial Pressure (CNAP) devices are a combination of the traditional Vascular Unloading Technique (VUT) and the VERIFI (Vasomotoric Elimination and Reconstructed Identification of the Initial set-point) mechanism. The hypothesis that the VERIFI mechanism (which deals with slow physiological rhythms and vasomotor changes) is mainly responsible for the accuracy of CNAP was tested in laboratory measurements with 20 subjects. The adapted CNAP software (with VERIFI only) followed changes in mean arterial blood pressure (BP) during extensive BP-changing maneuvers and was able to provide accurate mean arterial BP values comparable to those of the standard CNAP software: correlation was R=0.8873; average bias was 0.30 ± 4.47 mmHg (limits of agreement -8.46 to 9.06 mmHg); percentage error was 10.60 %. Thus, the VERIFI mechanism can be considered as mainly responsible for CNAP's overall accuracy.