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Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer

Nature Structural and Molecular Biology
DOI: 10.1038/nsmb.3240
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Abstract

The noncoding RNA LINP1 acts as a scaffold that links Ku and DNA-PKcs and enables efficient DNA double-strand-break repair through nonhomologous end joining (NHEJ), thereby enhancing the resistance of triple-negative breast cancer cells to radiation and chemotherapies.

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Lees-Miller, S. P., Beattie, T. L., & Tainer, J. A. (2016, June 7). Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer. Nature Structural and Molecular Biology. Nature Publishing Group. https://doi.org/10.1038/nsmb.3240

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