Solubility enhancement of oxcarbazepine by melt sonocrystallization technique to increase the bioavailability

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Abstract

Objectives: The present study aimed to enhance the solubility of Oxcarbazepine by melt sono crystallization technique as well as increase its bioavailability. Materials and Methods: Tablets of Melt Sonocrystallized Oxcarbazepine were prepared by the direct compression method. Compression was performed on a Remik mini-press tablet compression machine using an 8mm punch. The analytical method development was carried out in 20x10 and 10x10 twin trough chambers. The sample was spotted with a 100μl camas microliter syringe on silica gel aluminum plate 60 F254 (20X10) and (10x10) plate; Merck using a CAMAG Linomat-5 sample applicator. Results: The Oxcarbazepine had better solubility in the ph 6.8 buffer. The mobile phase selected for HPTLC was Ethyl acetate: Methanol in the ratio (8:2 v/v) with the Rf value 0.582. The formulation F2 containing 5% SSG showed a release of 90.51% and was considered as an optimized formulation based on several parameters such as friability (0.21%), disintegration time(27.8 sec) and in vitro dissolution studies.

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APA

Mastiholimath, V. S., Mashelkar, G. P., Mannur, V. S., Dandagi, P. M., & Khanal, P. (2021). Solubility enhancement of oxcarbazepine by melt sonocrystallization technique to increase the bioavailability. Indian Journal of Pharmaceutical Education and Research, 55(1), s56–s65. https://doi.org/10.5530/ijper.55.1s.37

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