PCR performance in the SARS-CoV-2 Omicron variant of concern?

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Abstract

The new SARS-CoV-2 Omicron variant (B.1.1.529) has been recently declared a Variant of Concern due to a series of important mutations in the viral spike protein and especially in the receptor-binding domain. While investigations into the spread of this new variant are ongoing, the first cases have been detected in Switzerland. Important questions have been raised: (1) Will the PCR assays commonly used to detect SARS-CoV-2 still work for the Omicron variant? (2) Can specific PCR features, e.g. S-gene dropout, be used to identify potential Omicron samples? In this minireview we provide current knowledge on the Omicron variant and guidance on its PCR validation.

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Metzger, C. M. J. A., Lienhard, R., Seth-Smith, H. M. B., Roloff, T., Wegner, F., Sieber, J., … Egli, A. (2021). PCR performance in the SARS-CoV-2 Omicron variant of concern? Swiss Medical Weekly, 151(49–50). https://doi.org/10.4414/SMW.2021.W30120

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