Synthesis and antimicrobial activity of bis[4-methoxy-3-(6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl) phenyl]methanes and bis[(triazolo[3,4-b]thiadiazepin-3-yl) phenyl]methanes

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Abstract

A series of novel bis[4-methoxy-3-(6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl)phenyl]methanes and bis[(triazolo[3,4-b]thiadiazepin-3-yl)phenyl]methanes (5a-e and 6a-e) has been synthesized and characterized by IR, 1H and 13C NMR, MS and elemental analysis. All the newly synthesized compounds were screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Klobsinella aerogenes and Chromobacterium violaceum and antifungal activity against Candida albicans, Aspergillus fumigatus, Trichophyton rubrum and Trichophyton mentagrophytes. Compounds 5b, 5d, 5e, 6b, 6c and 6e exhibited potent activity against the tested bacteria and fungi, and emerged as potential molecules for further development.

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APA

Srinivas, A. (2016). Synthesis and antimicrobial activity of bis[4-methoxy-3-(6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl) phenyl]methanes and bis[(triazolo[3,4-b]thiadiazepin-3-yl) phenyl]methanes. Acta Chimica Slovenica, 63(1), 173–179. https://doi.org/10.17344/acsi.2015.2124

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