Adaptation of intercalated cells along the collecting duct to systemic acid/base changes

Abstract

Collecting duct intercalated cells respond to short-term acid/base perturbations by rapidly shuttling H-ATPase to and from the plasma membrane. Purkerson et al. provide information on the regulation of the anion transporters during chronic acidosis and acute recovery (alkalosis). They found that the major mechanism for both acute and chronic states is regulation of both the H-ATPase and the anion exchangers plus changes in the overall expression level of these anion transporters in chronic adaptation. © 2010 International Society of Nephrology.